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Polymorphisms of CYP2C8 Alter First-Electron Transfer Kinetics and Increase Catalytic Uncoupling

William R Arnold1, Susan Zelasko2, Daryl D Meling3

  • 1Department of Biochemistry, University of Illinois Urbana-Champaign, 3813 Veterinary Medicine Basic Sciences Building, 2001 South Lincoln Avenue, Urbana, IL 61802, USA. william.arnold@ucsf.edu.

International Journal of Molecular Sciences
|September 22, 2019
PubMed
Summary

Genetic variations in Cytochrome P450 2C8 (CYP2C8) alter paclitaxel metabolism by increasing uncoupling and hydrogen peroxide production. These CYP2C8 polymorphisms disrupt electron transfer with cytochrome P450 reductase (CPR).

Keywords:
CYP2C8cytochrome P450 reductaseelectron transferpaclitaxelpolymorphismsreactive oxygen species

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