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Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
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Horizontal Gene Transfer and Its Association with Antibiotic Resistance in the Genus Aeromonas spp

J Manuel Bello-López1, Omar A Cabrero-Martínez2, Gabriela Ibáñez-Cervantes3,4

  • 1Unidad de Investigación, Hospital Juárez de México, Av. Instituto Politécnico Nacional 5160, Magdalena de las Salinas, Gustavo A. Madero, Mexico 07360, Mexico. juanmanuelbello81@hotmail.com.

Microorganisms
|September 22, 2019
PubMed

Insights

Multidrug resistant bacteria pose a global health threat. Horizontal gene transfer, particularly conjugation in *Aeromonas* spp. from water, accelerates the spread of antibiotic resistance, complicating infections.

Area of Science:

  • Microbiology
  • Genetics
  • Public Health

Background:

  • Multidrug resistant bacteria present a significant global public health challenge, linked to increased morbidity and mortality.
  • Bacterial resistance is encoded by the 'bacterial resistome', comprising intrinsic (mutation-based) and extrinsic (horizontal gene transfer-based) resistance.
  • Horizontal gene transfer, mediated by transduction, transformation, and conjugation, involves the 'bacterial mobilome'.

Purpose of the Study:

  • To discuss the public health implications of multidrug resistance emergence in *Aeromonas* spp.
  • To highlight the role of horizontal gene transfer, specifically conjugation, in spreading resistance in aquatic environments.
  • To examine the complex challenges posed by resistant bacterial infections originating from natural environments.

Main Methods:

  • Review of existing literature on bacterial resistance mechanisms.
  • Analysis of genetic material transfer via conjugation in *Aeromonas* spp.
  • Discussion of public health impacts of resistant bacterial infections.

Main Results:

  • *Aeromonas* spp. in water environments are implicated in the emergence of multidrug resistance.
  • Conjugation events facilitate the transfer of genetic material, contributing to resistance spread.
  • Acquisition of antibiotic resistance in natural environments poses risks through ingestion or direct contact.

Conclusions:

  • Horizontal gene transfer significantly contributes to the spread of multidrug resistance in bacteria like *Aeromonas* spp.
  • Resistant *Aeromonas* spp. from water environments represent a growing public health concern.
  • The complexity of eradicating infections caused by multidrug-resistant bacteria necessitates further research and intervention strategies.
Keywords:
Aeromonasantimicrobial resistancehorizontal gene transfer

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