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Updated: Jan 19, 2026

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy
Published on: May 31, 2017
[The Case of Fulminant Myocarditis]
V A Titov1, A A Shishkova1, L B Mitrofanova1
1Federal State Budgetary Institution "Almazov National Medical Research Centre" of the Ministry of Health of the Russian Federation.
Fulminant myocarditis (FM) is a severe heart condition requiring intensive care. Early diagnosis and treatment, guided by biopsy, lead to a favorable long-term prognosis in most cases.
Area of Science:
- Cardiology
- Pathology
Background:
- Fulminant myocarditis (FM) is a critical inflammatory heart condition.
- It rapidly progresses to acute heart failure, cardiogenic shock, or lethal arrhythmias.
- Intensive treatment, including mechanical support and transplantation, is often necessary.
Purpose of the Study:
- To present a clinical case of fulminant myocarditis.
- To review current literature on the diagnosis and treatment of FM.
Main Methods:
- Echocardiography for initial screening.
- Endomyocardial biopsy for definitive diagnosis (histology, immunohistochemistry, molecular-genetic analysis).
- Magnetic resonance imaging is often limited by patient instability.
Main Results:
- Histological findings are crucial for determining prognosis.
- Most patients experience a favorable long-term outcome after the acute inflammatory phase resolves.
Conclusions:
- Fulminant myocarditis necessitates prompt and aggressive management.
- Accurate diagnosis, primarily through endomyocardial biopsy, is key to effective treatment and improved prognosis.
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