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Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST

Published on: April 23, 2015

Mouse Models as Resources for Studying Infectious Diseases.

Sanjay Sarkar¹, Mark T Heise²

¹Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Clinical Therapeutics

|September 22, 2019

Summary

Genetically defined mouse models are crucial for understanding infectious disease pathogenesis and evaluating vaccines and therapies. This review covers common and novel mouse models for infectious disease research.

Keywords:

genetics host/pathogen interactions infectious diseases mouse models

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Area of Science:

Infectious Diseases
Immunology
Genetics

Background:

Mouse models are indispensable for studying pathogen mechanisms and disease progression.
Genetically modified mice (inbred, humanized, knockout) enable detailed investigation of host-pathogen interactions.
These models are vital for preclinical testing of vaccines and therapeutics.

Purpose of the Study:

To review commonly used mouse models for infectious disease research.
To highlight emerging mouse models, including the Collaborative Cross.
To underscore the utility of mouse models in understanding disease pathogenesis and treatment.

Main Methods:

Review of existing literature on mouse models in infectious disease research.
Discussion of genetically defined mouse strains (inbred, humanized, knockout).
Introduction of novel resources like the Collaborative Cross.

Main Results:

Established mouse models allow exploration of pathogen virulence and host immune responses.
Gene knockout and humanized mice elucidate the role of specific host factors in disease.
These models facilitate the identification of therapeutic targets and vaccine efficacy.

Conclusions:

Mouse models are essential for advancing our understanding of infectious diseases.
A diverse array of mouse models exists, with new resources continually emerging.
Continued use and development of mouse models are critical for combating infectious agents.