Related Experiment Video
Updated: Jan 19, 2026
A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Cerebral Oxygenation During Respiratory Events in Children with Sleep-Disordered Breathing and Associated Disorders
Laurence Tabone1, Sonia Khirani2, Jorge Olmo Arroyo3
1Research Unit French Institute of Health and Medical Research U 955, team 13, Créteil, France.
Insights
Cerebral oxygenation changes in children with sleep-disordered breathing (SDB) vary based on respiratory event type, SDB severity, and age. Near-infrared spectroscopy monitored these oxygenation changes during SDB events.
Area of Science:
- Pediatric Pulmonology
- Neuroscience
- Sleep Medicine
Background:
- Sleep-disordered breathing (SDB) is prevalent in children and can impact neurological function.
- Cerebral oxygenation monitoring is crucial for understanding the effects of SDB on the brain.
- Near-infrared spectroscopy (NIRS) offers a non-invasive method to assess cerebral oxygenation.
Purpose of the Study:
- To evaluate changes in cerebral oxygenation using NIRS during respiratory events in children with SDB.
- To determine the relationship between respiratory event characteristics and cerebral oxygenation variations.
- To identify factors influencing cerebral oxygenation changes in pediatric SDB.
Main Methods:
- Sixty-five children suspected of SDB underwent polysomnography with simultaneous NIRS monitoring.
- Respiratory events were classified by type, duration, and associated changes in oxygen saturation (SpO2) and cerebral tissue oxygenation index (TOI).
- Data were analyzed based on SDB severity and patient age.
Main Results:
- A total of 540 obstructive/mixed apneas, 172 central apneas, and 393 obstructive hypopneas were analyzed.
- Mean decreases in SpO2 and TOI were 4.1% and 3.4%, respectively.
- TOI decreases were significantly smaller for obstructive hypopneas than apneas and were less pronounced in milder SDB and older children (>7 years). TOI decreases correlated with SpO2 decreases, event duration, and age.
Conclusions:
- Cerebral oxygenation variations in children with SDB are influenced by the type of respiratory event, SDB severity, and age.
- NIRS can effectively detect changes in cerebral oxygenation during SDB events in children.
- These findings highlight the importance of considering event type, severity, and age when assessing the neurological impact of SDB.
Objectives:
To evaluate changes in cerebral oxygenation by means of near-infrared spectroscopy during respiratory events in children with sleep-disordered breathing (SDB) and associated disorders.
Study Design:
Sixty-five children suspected of having SDB underwent a respiratory polygraphy with simultaneous recording of cerebral oxygenation indices. Respiratory events were analyzed by type of event, duration, variations of pulse oximetry (oxygen saturation [SpO2]), cerebral tissue oxygenation index (TOI), and heart rate. Data were categorized according to the severity of SDB and age.
Results:
There were 540 obstructive and mixed apneas, 172 central apneas, and 393 obstructive hypopneas analyzed. The mean decreases in SpO2 and TOI were 4.1 ± 3.1% and 3.4 ± 2.8%, respectively. The mean TOI decrease was significantly smaller for obstructive hypopnea compared with apneas. The TOI decrease was significantly less in children with mild SDB as compared with those with moderate-to-severe SDB and in children >7 years as compared with those <7 years old. TOI decreases correlated significantly with SpO2 decreases, duration of event, and age, regardless of the type of event. In a multivariable regression model, predictive factors of TOI decreases were the type of respiratory event, SpO2 decrease, apnea-hypopnea index, and age.
Conclusions:
In children with SDB and associated disorders, cerebral oxygenation variations depend on the type of respiratory event, severity of SDB, and age.
More Related Videos
Related Concept Videos
01:30Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
01:19Special considerations while measuring oxygen saturation
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is...
01:23Acute Respiratory Failure-IV
01:26Respiratory Volumes and Capacities I
01:21Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:23Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...