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Association between plasma strontium, a bone-seeking element, and type 2 diabetes mellitus
Liangkai Chen1, Qianqian Guo1, Qiang Wang1
1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clinical Nutrition (Edinburgh, Scotland)
|September 22, 2019
Summary
Higher strontium levels in the blood are linked to a reduced risk of type 2 diabetes mellitus (T2DM) and impaired glucose regulation (IGR). This study explores the potential connection between strontium and metabolic health.
Area of Science:
- Biochemistry
- Metabolic Health
- Trace Elements
Background:
- Strontium is essential for bone metabolism.
- The role of strontium in glucose and lipid metabolism is not well understood.
- Diet and water are primary human sources of strontium.
Purpose of the Study:
- Investigate the association between plasma strontium levels and type 2 diabetes mellitus (T2DM).
- Examine the relationship between strontium and impaired glucose regulation (IGR).
- Explore potential mechanisms linking strontium to glucose and lipid metabolism.
Main Methods:
- A case-control study involving 1448 T2DM patients, 782 IGR patients, and 2230 controls.
- Plasma strontium and mineral levels measured using inductively coupled plasma mass spectrometry.
- Multivariable logistic regression analysis to assess associations.
Main Results:
- Plasma strontium was inversely associated with T2DM and IGR.
- Higher strontium levels correlated with significantly lower odds of T2DM and IGR.
- Strontium levels showed a negative association with total cholesterol, LDL cholesterol, and lipid peroxidation.
Conclusions:
- Elevated plasma strontium concentrations are associated with reduced odds of T2DM and IGR.
- Further research is needed to confirm these findings and elucidate underlying mechanisms.
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