Related Experiment Video
Updated: Aug 7, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
[Drug-induced Sweet's syndrome related to hydroxychloroquine: About 2 cases]
Introduction:
Hydroxychloroquine is widely prescribed in systemic lupus erythematosus. Dermatologic adverse drug reactions are rare but can mimic a disease specific manifestation of lupus. Exceptionally, Sweet's syndrome, or acute febrile neutrophilic dermatosis, may be drug-induced.
Case Reports:
Two patients aged 31 and 42 years were treated with hydroxychloroquine for systemic lupus and Sjogren's syndrome, respectively. Three weeks after starting treatment, they had a febrile, purple and erythematous papular rash of the trunk and limbs. There was a biological inflammatory syndrome and skin biopsy disclosed an infiltrate of the dermis rich in neutrophils. Lesions regressed after stopping hydroxychloroquine and introducing systemic corticosteroid therapy. Allergologic tests discussed the differential diagnosis with a delayed-type hypersensitivity reaction.
Conclusion:
We report two exceptional cases of drug-induced Sweet's syndrome related to hydroxychloroquine treatment in autoimmune rheumatic diseases.
Related Concept Videos
Drug Toxicity: Risk factors
Drug Toxicity: Dose-Dependent Reactions
Drug Toxicity: Allergic Reactions
Drug toxicity: Idiosyncratic Reactions
Chronic Kidney Disease II: Clinical Manifestations
Hyperosmolar Hyperglycemic State
