Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood groups in Newfoundlanders.

S Philipps1, H Kaita, M Lewis

  • 1Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Canada.

Gene Geography : a Computerized Bulletin on Human Gene Frequencies
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monitoring trends and determinants in cardiovascular disease in Germany: results of the MONICA Project Augsburg, 1985-1990.

MMWR. Morbidity and mortality weekly report·1992
Same author

Erythropoietin levels in amniotic fluid and extraembryonic coelomic fluid in the first trimester of pregnancy.

British journal of obstetrics and gynaecology·1992
Same author

cDNA clone of hepatitis A virus encoding a virulent virus: induction of viral hepatitis by direct nucleic acid transfection of marmosets.

Journal of virology·1992
Same author

Validating current immunization practice with young infants.

Pediatrics·1992
Same author

A serologic relationship among the NFLD, BOW, and Wu red cell antigens.

Transfusion·1992
Same author

Vertebral osteomyelitis following manipulation of spondylitic necks--a possible risk.

Paraplegia·1992
Same journal

Microheterogeneity and AMP-FLP analysis of the 3' flanking interleukin-6 VNTR polymorphism in central Spain.

Gene geography : a computerized bulletin on human gene frequencies·1997
Same journal

Study of a trimeric tandem repeat locus (SBMA) in the Basque population: comparison with other populations.

Gene geography : a computerized bulletin on human gene frequencies·1997
Same journal

A correction of the estimates of the least common cystic fibrosis (CF) mutations published by "The Cystic Fibrosis Genetic Analysis Consortium" in 1994.

Gene geography : a computerized bulletin on human gene frequencies·1997
Same journal

Distribution of 9 common mutations in the CFTR gene in Slovak cystic fibrosis patients.

Gene geography : a computerized bulletin on human gene frequencies·1997
Same journal

Preliminary estimation of the Y Alu polymorphic (YAP) element in the Romanian population.

Gene geography : a computerized bulletin on human gene frequencies·1997
Same journal

Frequency of the blood group antigen K and the A1A2BO groups in the Norwegian counties.

Gene geography : a computerized bulletin on human gene frequencies·1997
See all related articles

Newfoundland blood group allele distributions show no significant differences compared to Canadian Caucasians. However, six rare alleles were identified in this isolate population, suggesting potential genetic uniqueness.

Area of Science:

  • Population genetics
  • Immunogenetics
  • Human genetics

Background:

  • Blood group systems are crucial for transfusion medicine and understanding population diversity.
  • Isolate populations often exhibit unique genetic profiles due to founder effects and genetic drift.

Purpose of the Study:

  • To characterize the distribution of blood group system alleles in a random sample of the Newfoundland population.
  • To compare Newfoundland allele frequencies with relevant reference populations.
  • To identify and report rare alleles within the studied cohort.

Main Methods:

  • Analysis of 30 high and low incidence antigens.
  • Genotyping for 14 blood group systems.
  • Comparison of allele frequencies with founder populations and the general Canadian Caucasian population.

Related Experiment Videos

Main Results:

  • No significant differences were found when comparing Newfoundland allele distributions to founder populations or the Canadian Caucasian population.
  • Six rare alleles (IN*a, NFLD, TAR, RH*x, RH*w, RH*V) were identified in 234 individuals.
  • The observed frequency of rare alleles aligns with findings in other isolate populations.

Conclusions:

  • The genetic makeup of Newfoundland's blood group systems does not significantly deviate from broader Canadian populations.
  • The presence of rare alleles warrants further investigation into the genetic characteristics of this isolate population.