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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable nanoclay gels for angiogenesis.

Daniel J Page1, Claire E Clarkin2, Raj Mani1

  • 1Centre for Human Development, Stem Cells and Regeneration, Bioengineering Sciences, University of Southampton Faculty of Medicine, Tremona Road, Southampton SO16 6YD, United Kingdom.

Acta Biomaterialia
|September 22, 2019
PubMed
Summary
This summary is machine-generated.

Injectable nanoclay gels effectively stabilize vascular endothelial growth factor (VEGF), promoting sustained blood vessel growth for regenerative medicine applications. This method enhances therapeutic protein delivery without complex engineering.

Keywords:
AngiogenesisClayGrowth factorsNanoclayNanosilicateVEGF

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Vascular Biology

Background:

  • Therapeutic protein delivery requires retention and sustained activity at target sites.
  • Vascular endothelial growth factor (VEGF) promotes blood vessel growth but is unstable in inflammatory environments.
  • Existing carriers often fail to stabilize VEGF, limiting its therapeutic potential.

Purpose of the Study:

  • To evaluate injectable Laponite™ XLG nanoclay gels as a carrier for stabilizing VEGF.
  • To determine if Laponite-VEGF gels enhance VEGF activity and retention in vitro and in vivo.
  • To assess the potential of this delivery system for regenerative medicine applications.

Main Methods:

  • VEGF was incorporated into Laponite™ XLG nanoclay gels.
  • In vitro tubulogenesis assays were used to assess VEGF activity.
  • In vivo subcutaneous injections in mice were performed to evaluate gel retention and angiogenesis via CD31 staining.

Main Results:

  • VEGF-Laponite gels demonstrated dose-dependent enhancement of in vitro tubulogenesis.
  • In vivo, Laponite gels were retained at the injection site for up to three weeks.
  • A four-fold increase in blood vessel formation was observed in vivo compared to alginate or vehicle controls.

Conclusions:

  • Injectable Laponite™ XLG nanoclay gels effectively stabilize and retain bioactive VEGF.
  • This delivery system significantly enhances VEGF-mediated angiogenesis in vivo.
  • The Laponite-VEGF approach offers a robust, non-complex method for delivering therapeutic growth factors for regenerative purposes, potentially aiding wound healing.