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Updated: Jan 19, 2026

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Rotavirus-Induced Neonatal Epileptic Encephalopathy-A Disease Spectrum Illustrated by Monochorionic Twins

Esther M Hopmans1, Astrid van der Heide1,2, Pui Khi Chung3

  • 1Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, Leiden, The Netherlands.

Neuropediatrics
|September 22, 2019
PubMed

Insights

Rotavirus infection in newborns can cause seizures and white matter changes on MRI. This study identifies rotavirus as a potential cause of early infantile epileptic encephalopathy (EIEE) with a better prognosis.

Area of Science:

  • Neurology
  • Virology
  • Pediatrics

Background:

  • Rotavirus is a known cause of neonatal seizures and white matter abnormalities on MRI.
  • Early infantile epileptic encephalopathy (EIEE) is typically associated with a poor prognosis.

Observation:

  • Monochorionic twins presented with rotavirus infection, white matter MRI abnormalities, and an EIEE EEG pattern.
  • One twin exhibited subtle neurological symptoms despite MRI and EEG evidence of rotavirus encephalopathy.

Findings:

  • Rotavirus infection should be considered a cause of EIEE EEG patterns.
  • The prognosis for EIEE associated with rotavirus may be more favorable than previously thought.

Implications:

  • Rotavirus infection is a potential cause of EIEE and should be included in the differential diagnosis for neonatal seizures.
  • Subtle or insidious central nervous system complications due to rotavirus may be more common than recognized.
  • This finding broadens the understanding of rotavirus's neurological impact in neonates.

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