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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.5K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Transcytosis of IgG01:15

Transcytosis of IgG

4.1K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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The landscape of serum autoantibodies in lupus nephritis.

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Correction: Anti-β2GPI IgG display a broad reactivity against different β2GPI domains beyond domain 1: results from the APS ACTION and multi-center Italian cohorts.

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Anti-β2GPI IgG display a broad reactivity against different β2GPI domains beyond domain 1: results from the APS ACTION and multi-center Italian cohorts.

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Impact of the 2023 ACR/EULAR antiphospholipid syndrome criteria in 1200 women with prior obstetric antiphospholipid syndrome.

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Related Experiment Video

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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Autoimmune diseases and pregnancy.

Angela Tincani1, Cecilia Nalli2, Jamilya Khizroeva3

  • 1Rheumatology and Immunology Unit, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili, Brescia, Italy; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russia.

Best Practice & Research. Clinical Endocrinology & Metabolism
|September 23, 2019
PubMed
Summary

Women with autoimmune diseases like Systemic Lupus Erythematosus can now have healthy pregnancies with proper medical guidance. Careful counseling on medication safety and managing risk factors like antiphospholipid antibodies is crucial for successful outcomes.

Keywords:
autoimmune diseasespregnancysystematic review

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Area of Science:

  • Rheumatology
  • Obstetrics
  • Immunology

Background:

  • Pregnancy in women with autoimmune diseases presents complex challenges.
  • Historically, pregnancy in these conditions was often discouraged due to risks.

Purpose of the Study:

  • To highlight advancements in managing pregnancy for women with autoimmune diseases.
  • To emphasize the importance of multidisciplinary care and patient counseling.

Main Methods:

  • Review of current medical understanding and management strategies.
  • Focus on risk factor identification and mitigation.

Main Results:

  • Significant improvements allow women with Systemic Lupus Erythematosus and Antiphospholipid Syndrome to achieve healthy pregnancies.
  • Effective management of maternal risk factors (e.g., antiphospholipid antibodies, anti-Ro/SSA antibodies) and disease activity is key.

Conclusions:

  • Optimal medical support requires a multidisciplinary approach involving rheumatologists and obstetricians.
  • Comprehensive counseling regarding medication safety and risk management is essential before, during, and after pregnancy.