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Prognostic factors in Krukenberg tumor
Ruggero Lionetti1, Marcello De Luca1, Antonio Travaglino2
1Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.
Archives of Gynecology and Obstetrics
|September 23, 2019
Summary
Peritoneal involvement, ascites, synchronous presentation, and elevated CEA levels are poor prognostic indicators for Krukenberg tumors (KT). These factors significantly decrease overall survival in patients with this rare ovarian cancer.
Area of Science:
- Gynecology
- Oncology
- Pathology
Background:
- Krukenberg tumor (KT) is a rare type of secondary ovarian malignancy.
- Limited understanding exists regarding prognostic factors influencing KT outcomes.
Purpose of the Study:
- To systematically review and meta-analyze clinicopathologic factors associated with prognosis in Krukenberg tumors.
- To identify key indicators of overall survival in KT patients.
Main Methods:
- A comprehensive search of electronic databases was conducted up to February 2019.
- Studies correlating clinicopathologic factors with overall survival in KT were included.
- Pooled hazard ratios (HR) were calculated, with p < 0.05 considered significant.
Main Results:
- The meta-analysis included 23 studies with 1743 patients.
- Factors significantly associated with decreased overall survival included peritoneal involvement (HR 1.944), ascites (HR 2.055), synchronous presentation (HR 1.679), and elevated serum CEA levels (HR 1.380).
- Age, menopausal status, tumor size, bilaterality, metastasis, and CA125/CA19.9 levels did not show significant prognostic value.
Conclusions:
- Peritoneal involvement, ascites, synchronous presentation, and elevated serum CEA levels are identified as adverse prognostic factors for Krukenberg tumors.
- These findings may inform patient management strategies for KT.
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