Related Experiment Video
Updated: Jan 19, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Sensitivity Analysis and Extensions of Testing the Causal Direction of Dependence: A Rejoinder to Thoemmes (2019)
Wolfgang Wiedermann1, James Sebastian1
1University of Missouri.
Abstract:
A commentary by Thoemmes on Wiedermann and Sebastian's introductory article on Direction Dependence Analysis (DDA) is responded to in the interest of elaborating and extending direction dependence principles to evaluate causal effect directionality. Considering Thoemmes' observation that some DDA principles are already well-established in machine learning, we argue that several other connections between DDA and research lines in theoretical statistics, econometrics, and quantitative psychology exist, suggesting that DDA is best conceptualized as a framework that summarizes and extends existing knowledge on properties of linear models under non-normality. Further, Thoemmes articulates concerns about assumptions of error distributions used in our main article and presents an artificial data example in which some DDA tests have suboptimal statistical power. We present extensions of DDA to entirely relax distributional assumptions about errors and describe two sensitivity analysis approaches to critically evaluate DDA results. Both sensitivity approaches are illustrated using Thoemmes' artificial data example. Incorporating DDA sensitivity results yields correct causal conclusions. Thus, overall, we stay with our initial conclusion that the use of higher moments in causal inference constitutes an exciting open research area.
More Related Videos
06:45Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal
Published on: April 18, 2017
10:26Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
Published on: September 11, 2021
Related Concept Videos
Criteria for Causality: Bradford Hill Criteria - II
Introduction to Test of Independence
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
Hypothesis Test for Test of Independence
H0: The two variables (factors)...
Causality in Epidemiology
Statistical Hypothesis Testing
Statistical significance measures the probability that an observed result occurred by chance. If this probability, known as...
Criteria for Causality: Bradford Hill Criteria - I