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Updated: Jan 19, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Selective Inhibitors of Nuclear Export in the Treatment of Hematologic Malignancies

Alessandro Allegra1, Vanessa Innao1, Andrea Gaetano Allegra1

  • 1Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi," University of Messina, Messina, Italy.

Clinical Lymphoma, Myeloma & Leukemia
|September 24, 2019
PubMed

Insights

Selective inhibitors of nuclear export (SINEs) are a novel class of antitumor agents targeting Exportin 1 (XPO1). These drugs show promise in treating various blood cancers, with ongoing studies to define their clinical role.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Cellular homeostasis relies on precise molecular localization between the nucleus and cytoplasm.
  • Exportin 1 (XPO1) is a key regulator of nuclear-cytoplasmic transport for cancer-related proteins.

Purpose of the Study:

  • To review the development and therapeutic potential of selective inhibitors of nuclear export (SINEs).
  • To discuss the mechanism of action and clinical efficacy of SINEs in hematological malignancies.

Main Methods:

  • Review of preclinical studies and clinical trials on SINEs.
  • Analysis of SINEs' mechanism of action and effects on cancer cells.

Main Results:

  • SINEs represent a promising new class of antitumor agents.
  • Preclinical and clinical data indicate efficacy in multiple myeloma, lymphomas, and leukemias.

Conclusions:

  • Selective inhibitors of nuclear export (SINEs) demonstrate significant therapeutic potential in various hematological cancers.
  • Further research is expected to establish the role of SINEs in routine clinical practice for cancer treatment.
Keywords:
Exportin 1KaryopherinsLeukemiaMultiple myelomaSelinexor

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