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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

Romain Guièze1, Vivian M Liu2, Daniel Rosebrock3

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana Building, Room DA-520, Boston MA 02215-02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA; CHU de Clermont-Ferrand, 63000 Clermont-Ferrand, France; Université Clermont Auvergne, EA7453 CHELTER, 63000 Clermont-Ferrand, France.

Cancer Cell
|September 24, 2019
PubMed

Keywords:
AMPKBCL-2CRISPR/Cas9chronic lymphocytic leukemiaclonal evolutiondrug resistancegenome-wide screenmetabolismmitochondrionvenetoclax

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