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Exploring a Ring-Closing Metathesis Approach to the Archazolid Macrocycle.

Brianne R King1, Steven M Swick1, Sara L Schaefer1

  • 1Department of Chemistry, Western Washington University, Bellingham, WA 98225.

Synthesis
|September 24, 2019
PubMed
Summary

Researchers synthesized a novel dihydroarchazolid analogue domain and explored macrocyclization using ring-closing metathesis (RCM). A competing backbiting reaction was identified, potentially solvable with alcohol functionalization and a metathesis relay.

Keywords:
Natural productsOlefin metathesisRelay ring-closing metathesisTotal synthesis

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