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Related Experiment Video

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Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
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Higher interleukin-33 levels in aggressive periodontitis cases.

Sujatha Pai Ballambettu1,2, A R Pradeep2,3, Meera Purushottam4

  • 1Department of Periodontology, DSCDS, Bengaluru, Karnataka, India.

Journal of Indian Society of Periodontology
|September 24, 2019
PubMed
Summary

Interleukin-33 (IL-33) levels in gingival crevicular fluid and plasma are higher in periodontitis patients. The GG genotype of IL-33 SNP rs1157505 is associated with elevated IL-33 and generalized aggressive periodontitis.

Keywords:
Aggressive periodontitischronic periodontitisgenetic polymorphismgingival crevicular fluidinterleukin

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Area of Science:

  • Periodontology
  • Immunology
  • Genetics

Background:

  • Interleukin-33 (IL-33) is an alarmin released during tissue damage.
  • IL-33 plays a role in immune responses.
  • Its role in periodontitis pathogenesis is not fully understood.

Purpose of the Study:

  • To analyze IL-33 concentrations in gingival crevicular fluid (GCF) and plasma.
  • To correlate IL-33 levels with periodontitis severity (chronic and aggressive).
  • To investigate the association between IL-33 gene intronic variants (SNPs rs1157505 and rs7044343) and IL-33 concentrations in periodontitis patients.

Main Methods:

  • Cross-sectional, biochemical, and genetic study design.
  • Ninety subjects categorized into healthy, chronic periodontitis, and generalized aggressive periodontitis groups.
  • Quantification of IL-33 in GCF and plasma using ELISA; SNP analysis via PCR-RFLP.

Main Results:

  • Significant differences in GCF and plasma IL-33 concentrations were observed across the three groups.
  • The GG genotype of IL-33 SNP rs1157505 was linked to the highest IL-33 levels in both GCF and plasma.
  • This GG genotype was significantly more prevalent in generalized aggressive periodontitis patients compared to healthy and chronic periodontitis groups. SNP rs7044343 showed no significant association.

Conclusions:

  • IL-33 may serve as a potential inflammatory biomarker for periodontitis.
  • The GG genotype of IL-33 SNP rs1157505 may be associated with the development or severity of generalized aggressive periodontitis.