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Lichen Planus and Metabolic Syndrome: Is There a Relation?
Rohit Singla1,2, P K Ashwini1, Betkerur Jayadev1
1Department of Dermatology and Venereology, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
Indian Dermatology Online Journal
|September 24, 2019
Summary
Lichen planus (LP) patients show a higher prevalence of metabolic syndrome (MS), diabetes mellitus, and dyslipidemia. Early detection and treatment of these conditions in LP patients can improve cardiovascular health.
Area of Science:
- Dermatology
- Endocrinology
- Cardiovascular Medicine
Background:
- Lichen planus (LP) is increasingly associated with systemic disorders.
- The relationship between LP and metabolic syndrome (MS) requires further investigation.
- Metabolic syndrome is a known risk factor for cardiovascular diseases.
Purpose of the Study:
- To investigate the association between Lichen Planus (LP) and Metabolic Syndrome (MS).
Main Methods:
- Investigated 100 LP patients and 50 healthy controls.
- Assessed fasting blood glucose (FBS) and lipid profiles.
- Diagnosed MS using National Cholesterol Education Program's Adult Treatment Panel III guidelines.
Main Results:
- LP patients exhibited significantly higher serum cholesterol, triglycerides, LDL-C, and VLDL-C levels compared to controls.
- Elevated FBS was observed in 42% of LP patients versus 10% of controls (P=0.0003).
- MS prevalence was higher in LP patients (43%) than in controls (26%) (P=0.045).
Conclusions:
- Lichen planus patients have a higher incidence of diabetes mellitus, dyslipidemia, and metabolic syndrome.
- These findings suggest a potential link between LP and metabolic disturbances.
- Further research is needed to confirm these associations globally.
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