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Granulomatous Variant of Giant Centrifugal Miliaria Profunda in a Hypothyroid Infant: A Case Report
Akansha A Chadha1, Sunanda A Mahajan1, Atul Dongre1
1Department of Dermatology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Abstract:
The miliarias are a clinically heterogeneous group of diseases which occur when the free flow of eccrine sweat to the skin surface is impeded. Miliaria profunda is a variant with obstruction of the duct at or below the level of dermoepidermal junction. The giant centrifugal variant of miliaria profunda has been described in the past at the sites of occlusive tapes and in febrile patients. Thyroid hormone has a regulatory effect on the skin and its appendages and an association of hypothyroidism with this variant of miliaria profunda has not been described in the past. We report a case of giant centrifugal miliaria profunda in an infant with congenital hypothyroidism.
Insights
Giant centrifugal miliaria profunda, a rare skin condition, was observed in an infant with congenital hypothyroidism. This case highlights a previously undescribed association between hypothyroidism and this specific miliaria variant.
Area of Science:
- Dermatology
- Endocrinology
- Pediatrics
Background:
- Miliarias are skin conditions caused by blocked eccrine sweat ducts.
- Miliaria profunda involves duct obstruction at or below the dermoepidermal junction.
- Giant centrifugal miliaria profunda is a rare variant previously linked to occlusive tapes and fever.
Observation:
- A case of giant centrifugal miliaria profunda in an infant is presented.
- The infant was diagnosed with congenital hypothyroidism.
Findings:
- This report describes a novel association between congenital hypothyroidism and giant centrifugal miliaria profunda.
- Thyroid hormone's regulatory role in skin appendages is acknowledged, but this specific link was previously undocumented.
Implications:
- This finding may expand the understanding of miliaria profunda's pathophysiology.
- It suggests screening for hypothyroidism in infants with this rare skin condition.
- Further research is warranted to explore the endocrine-dermatological connection in miliaria.
