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Factors influencing the transfusion effect
1Eurotransplant Foundation, University Hospital-Leiden, The Netherlands.
Pretransplant blood transfusions can improve kidney graft survival, but they risk sensitizing the patient. One transfusion induces the beneficial transfusion effect and has a minimal risk for sensitization. Recipients with different HLA-DR phenotypes may need different numbers of transfusions to improve graft survival. For nontransfused recipients it is important to receive a well-matched HLA-DR kidney.
Pretransplant blood transfusions can improve kidney graft survival, but they risk sensitizing the patient. One transfusion induces the beneficial transfusion effect and has a minimal risk for sensitization. Recipients with different HLA-DR phenotypes may need different numbers of transfusions to improve graft survival. For nontransfused recipients it is important to receive a well-matched HLA-DR kidney.