The role of dNTP metabolites in control of the embryonic cell cycle
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Updated: Jan 19, 2026

Spatiotemporal Subcellular Manipulation of the Microtubule Cytoskeleton in the Living Preimplantation Mouse Embryo using Photostatins
Published on: November 30, 2021
Boyang Liu1, Jörg Großhans1,2
1Institut für Entwicklungsbiochemie, Universitätsmedizin, Georg-August-Universität , Göttingen , Germany.
Abstract:
Deoxyribonucleotide metabolites (dNTPs) are the substrates for DNA synthesis. It has been proposed that their availability influences the progression of the cell cycle during development and pathological situations such as tumor growth. The mechanism has remained unclear for the link between cell cycle and dNTP levels beyond their role as substrates. Here, we review recent studies concerned with the dynamics of dNTP levels in early embryos and the role of DNA replication checkpoint as a sensor of dNTP levels.
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