Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The transfusion effect.

Y Iwaki, J M Cecka, P I Terasaki

    Clinical Transplants
    |January 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Pretransplant blood transfusions significantly improve cadaver kidney transplant survival, especially with mismatched kidneys. The transfusion effect is most pronounced in younger patients and Black recipients, though it has diminished over time.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Paul I. Terasaki, PhD, 1929-2016.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
    Same author

    HLA high-resolution typing for sensitized patients: a solution in search of a problem?

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    Kidney paired donation in the presence of donor-specific antibodies.

    Kidney international·2013
    Same author

    Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
    Same author

    Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
    Same author

    HLA matching for organ transplantation…why not?

    International journal of immunogenetics·2010
    Same journal

    Clinical Relevance of Donor-Specific IgM Antibodies in HLA Incompatible Renal Transplantation: A Retrospective Single-Center Study.

    Clinical transplants·2017
    Same journal

    Influenza Immunization and the Generation of Anti-HLA and Anti-MICA Antibodies in Patients with Renal Failure and in Kidney Transplant Recipients.

    Clinical transplants·2017
    Same journal

    From Accurate Assessment of Anti-HLA Antibody MFI to Complement-Binding Assays.

    Clinical transplants·2017
    Same journal

    Post-transplant Desensitization for Deceased Donor Kidney Transplant Recipients: A Single Center Experience.

    Clinical transplants·2017
    Same journal

    Acute Rejection in 6-Antigen HLA-Matched Kidney Transplant Recipients: Risk Factors and Outcomes from the Wisconsin Allograft Recipient Database (WisARD).

    Clinical transplants·2017
    Same journal

    C1q Donor-Specific Antibody Associates with Post-transplant Biopsy Findings in Highly- Sensitized Kidney Transplant Recipients.

    Clinical transplants·2017
    See all related articles

    Area of Science:

    • Nephrology
    • Immunology
    • Transplantation

    Background:

    • The
    • transfusion effect
    • in kidney transplantation refers to improved graft survival following blood transfusions prior to transplantation.
    • Historically, pretransplant transfusions were common, but their use has declined.
    • Factors such as patient age, HLA matching, and recipient race may influence this effect.

    Purpose of the Study:

    • To analyze the historical trends and influencing factors of the transfusion effect on cadaver kidney transplant outcomes.

    Main Methods:

    • Retrospective analysis of cadaver kidney transplant recipient data.
    • Evaluation of 1-year graft survival rates based on transfusion status, age, HLA matching (A, B, DR), and recipient race.

    Related Experiment Videos

  • Assessment of changes in transfusion practices and their impact over different time periods.

    • Main Results:

    • A significant "transfusion effect" was observed, improving 1-year graft survival by 7.1% in 1987 (p<0.0002).
    • The effect was greatest in younger recipients (17% for ages 16-25) and diminished with age.
    • Transfusions provided a substantial benefit for recipients with mismatched kidneys (up to 8% for A, B, DR mismatched and 8-10% for DR mismatched), but not for 0 DR-mismatched transplants.
    • The transfusion effect was more pronounced in Black recipients (8%) compared to White recipients (4%).
    • The proportion of non-transfused first cadaver kidney transplants increased from 10% (1981-1984) to approximately 25% in 1988.

    Conclusions:

    • Pretransplant blood transfusions remain a critical factor in enhancing cadaver kidney allograft survival, particularly in the context of HLA mismatch.
    • The declining use of transfusions may impact graft survival rates, especially given the diminishing transfusion effect with increasing patient age.
    • Optimizing transfusion strategies based on recipient characteristics and HLA matching is essential for maximizing kidney transplant success.