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Related Experiment Videos

Donor age and recipient age.

S Takemoto, P I Terasaki

    Clinical Transplants
    |January 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Kidney transplant graft survival is significantly lower with older donors, especially after 1985, potentially due to immunosuppressive drugs. Recipient age impacts patient survival, with older recipients experiencing more non-immunologic failures.

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    Area of Science:

    • Nephrology
    • Transplantation immunology
    • Geriatric medicine

    Background:

    • Donor age is a critical factor influencing kidney transplant outcomes.
    • Recipient age also plays a role in patient survival and graft success.
    • The use of older donors and recipients has increased over time.

    Purpose of the Study:

    • To investigate the impact of donor and recipient age on kidney transplant graft and patient survival.
    • To analyze trends in donor and recipient age over a decade.
    • To identify factors associated with graft failure in relation to age.

    Main Methods:

    • Retrospective analysis of kidney transplant data.
    • Comparison of graft survival rates based on donor age groups (e.g., <30, 50, 65 years).

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  • Evaluation of patient survival and failure types (immunologic vs. non-immunologic) in relation to recipient age.

    • Main Results:

    • Kidneys from older donors (e.g., >50 years) showed markedly lower 1-year graft survival rates compared to younger donors.
    • The negative impact of older donor age on graft survival was more pronounced after 1985, coinciding with the use of Cyclosporine A (CsA).
    • Older recipients (>50 years) had reduced patient survival and an increased incidence of non-immunologic graft failures, despite higher graft survival in non-transfused patients.

    Conclusions:

    • Donor age is a significant predictor of kidney transplant graft survival, with younger donors yielding better outcomes.
    • Recipient age is strongly associated with patient survival and the pattern of graft failure, highlighting the need for age-specific management strategies.
    • While donor age remains a concern, further research is needed to assess its impact in the context of modern immunosuppressive therapies like CsA.