Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical transplants 1988. Overview.

P I Terasaki, J M Cecka, S Takemoto

    Clinical Transplants
    |January 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Paul I. Terasaki, PhD, 1929-2016.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
    Same author

    HLA high-resolution typing for sensitized patients: a solution in search of a problem?

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    Kidney paired donation in the presence of donor-specific antibodies.

    Kidney international·2013
    Same author

    SEROTYPING FOR HOMOTRANSPLANTATION. VII. SELECTION OF KIDNEY DONORS FOR THIRTY-TWO RECIPIENTS.

    Annals of the New York Academy of Sciences·2010
    Same author

    Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
    Same author

    Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
    Same journal

    Clinical Relevance of Donor-Specific IgM Antibodies in HLA Incompatible Renal Transplantation: A Retrospective Single-Center Study.

    Clinical transplants·2017
    Same journal

    Influenza Immunization and the Generation of Anti-HLA and Anti-MICA Antibodies in Patients with Renal Failure and in Kidney Transplant Recipients.

    Clinical transplants·2017
    Same journal

    From Accurate Assessment of Anti-HLA Antibody MFI to Complement-Binding Assays.

    Clinical transplants·2017
    Same journal

    Post-transplant Desensitization for Deceased Donor Kidney Transplant Recipients: A Single Center Experience.

    Clinical transplants·2017
    Same journal

    Acute Rejection in 6-Antigen HLA-Matched Kidney Transplant Recipients: Risk Factors and Outcomes from the Wisconsin Allograft Recipient Database (WisARD).

    Clinical transplants·2017
    Same journal

    C1q Donor-Specific Antibody Associates with Post-transplant Biopsy Findings in Highly- Sensitized Kidney Transplant Recipients.

    Clinical transplants·2017
    See all related articles

    Six-antigen matched transplants significantly improve graft survival rates compared to controls. Advanced matching and crossmatch techniques enhance transplant success, highlighting the importance of histocompatibility in kidney transplantation.

    Area of Science:

    • Nephrology
    • Immunology
    • Transplantation Science

    Background:

    • Kidney transplant outcomes have historically varied due to factors like donor-recipient matching and pre-transplant antibodies.
    • The impact of specific matching strategies and crossmatch techniques on long-term graft survival requires ongoing investigation.
    • Center-specific performance and evolving immunosuppression protocols influence transplant success rates.

    Purpose of the Study:

    • To evaluate the impact of six-antigen matched kidney transplants on graft survival.
    • To assess the role of HLA matching, preformed antibodies, and crossmatch techniques in transplant outcomes.
    • To analyze the influence of center effects and immunosuppression on long-term graft survival.

    Main Methods:

    • Analysis of graft survival data from the UNOS program, comparing 6-antigen matched transplants with controls.

    Related Experiment Videos

  • Review of individual center data and historical transplant performance metrics.
  • Evaluation of the association between preformed antibodies, flow cytometry crossmatches (including platelet crossmatch and DTT testing), and graft outcomes.

    • Main Results:

    • Three-month and 1-year graft survival were significantly higher for 6-antigen matched transplants (96% and 89%) compared to controls (85% and 78%).
    • HLA matching demonstrated a substantial difference in 1-year graft survival for cadaver donor transplants, with a widening gap over 3 years.
    • Negative platelet crossmatches showed a higher 1-month graft function rate (100%) compared to positive crossmatches (42%). DTT testing identified false positive crossmatches, leading to 94% 1-month function.

    Conclusions:

    • Six-antigen matching is a critical factor in improving kidney transplant graft survival.
    • Advanced crossmatch techniques, such as platelet flow cytometry and DTT testing, refine patient selection and improve early graft function.
    • While center effects are significant for cadaveric transplants, histocompatibility minimizes these differences, underscoring the importance of donor-recipient compatibility.