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Epilepsy, psychosis and schizophrenia
1Neuropsychiatry Branch, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, DC 20032.
Schizophrenia Research
|January 1, 1988
Summary
Researchers reviewed evidence linking temporal lobe epilepsy (TLE) and schizophrenia. Hypotheses are considered for the increased incidence of both conditions after adolescence.
Area of Science:
- Neuroscience
- Psychiatry
- Epileptology
Background:
- A proposed link exists between temporal lobe epilepsy (TLE) and schizophrenia.
- This connection is supported and challenged by existing research.
Purpose of the Study:
- To review evidence for the association between TLE and schizophrenia.
- To explore hypotheses explaining the co-occurrence of these conditions.
Main Methods:
- Literature review of studies investigating the epilepsy-schizophrenia link.
- Analysis of evidence supporting and refuting the proposed connection.
Main Results:
- The review synthesizes findings on the comorbidity of TLE and schizophrenia.
- Identified hypotheses address the increased incidence post-adolescence.
Conclusions:
- The relationship between TLE and schizophrenia warrants further investigation.
- Understanding shared underlying mechanisms may be key.