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Updated: Jan 19, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
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MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

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LncRNA IUR downregulates ZEB1 by upregulating miR-200 to inhibit prostate carcinoma

Lingjun Sun1, Taowei Chen1, Tao Li1

  • 1Urology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang, China.

Physiological Genomics
|September 24, 2019
PubMed

Insights

Imatinib-upregulated lncRNA (IUR) is downregulated in prostate carcinoma (PC), inhibiting cancer cell invasion and migration. IUR upregulates microRNA-200, which downregulates ZEB1, a key factor in PC progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate carcinoma (PC) is a significant health concern.
  • The role of long non-coding RNAs (lncRNAs) in PC progression is increasingly recognized.
  • Imatinib-upregulated lncRNA (IUR) is a novel lncRNA implicated in cancer.

Purpose of the Study:

  • To investigate the role of IUR in prostate carcinoma.
  • To elucidate the molecular mechanism by which IUR affects PC cell behavior.
  • To explore the relationship between IUR, microRNA-200 (miR-200), and ZEB1 in PC.

Main Methods:

  • Analysis of IUR expression in PC tissues and correlation with clinical stages.
  • Investigation of the regulatory relationship between IUR, miR-200, and ZEB1 in PC cells.
  • Overexpression studies of IUR, miR-200, and ZEB1 in PC cells.
  • Cell invasion and migration assays.

Main Results:

  • IUR was found to be downregulated in PC tissues, with decreased expression correlating with advanced clinical stages.
  • IUR and miR-200 overexpression led to decreased PC cell invasion and migration.
  • IUR overexpression upregulated miR-200, which in turn downregulated ZEB1.
  • ZEB1 overexpression counteracted the inhibitory effects of IUR and miR-200.

Conclusions:

  • IUR acts as a tumor suppressor in prostate carcinoma.
  • IUR inhibits PC cell invasion and migration by upregulating miR-200 and subsequently downregulating ZEB1.
  • IUR represents a potential therapeutic target for prostate carcinoma.
Keywords:
ZEB1lncRNA IURmiR-200prostate carcinoma

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