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Hyperstable arousal regulation in multiple sclerosis.

Muriel Stoppe1, Klara Meyer2, Maike Schlingmann2

  • 1Department of Neurology, University of Leipzig, Germany; Translational Centre for Regenerative Medicine, University of Leipzig, Germany.

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|September 24, 2019
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis patients show altered arousal patterns, with a higher frequency of hyperstable arousal. While fatigue is linked to arousal dysregulation, the association with hypothalamic-pituitary-adrenal (HPA) axis activity was weak in this study.

Keywords:
ArousalFatigueHypothalamic pituitary adrenal axisMultiple sclerosisVIGALL

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychiatry

Background:

  • Fatigue is a prevalent symptom in multiple sclerosis (MS).
  • Altered arousal regulation and hypothalamic-pituitary-adrenal (HPA) axis activity are implicated in fatigue.
  • Specific arousal patterns (hyperstable and unstable) are linked to fatigue in depression and cancer.

Purpose of the Study:

  • To investigate arousal regulation patterns in MS patients.
  • To determine if fatigue in MS can be physiologically described by altered arousal regulation.
  • To examine the relationship between HPA axis activity and different arousal regulation types in MS.

Main Methods:

  • Analysis of 51 relapsing-remitting MS patients and 20 healthy controls.
  • Utilized the Vigilance Algorithm Leipzig for arousal assessment.
  • Employed a combined dexamethasone/corticotropin-releasing hormone (CRH) test to evaluate HPA axis activity.

Main Results:

  • MS patients exhibited a significantly higher frequency of hyperstable arousal compared to controls (62.7% vs. 45.0%).
  • Patients reported higher fatigue levels, irrespective of arousal pattern.
  • Mild HPA axis activation was observed in MS patients; HPA activity was highest in hyperstable and lowest in unstable arousal patterns.

Conclusions:

  • Arousal pattern frequencies are altered in multiple sclerosis.
  • The association between arousal patterns and HPA axis activity in MS may be weak, potentially due to stable disease status on immunotherapy.