1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and...

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Oncology

Background:

• Current anticancer agents face challenges with side effects and drug resistance.
• The 1,2,3-triazole scaffold is a recognized building block for developing new anticancer drugs.
• Hybrid molecules integrating 1,2,3-triazole with other pharmacophores are being explored for enhanced cancer therapy.

Purpose of the Study:

• To review recent advances in 1,2,3-triazole-containing hybrid anticancer agents.
• To discuss structure-activity relationships (SAR) of these hybrid compounds.
• To explore the mechanisms of action for novel anticancer therapeutics.

Main Methods:

• Literature review of studies published between 2015 and 2019.
• Analysis of structure-activity relationships for identified hybrid molecules.
• Discussion of reported mechanisms of action for anticancer activity.

Main Results:

• Identified numerous 1,2,3-triazole-based hybrid molecules with significant anticancer potential.
• Highlighted key structural features contributing to anticancer efficacy.
• Summarized diverse mechanisms of action, including enzyme inhibition and apoptosis induction.

Conclusions:

• 1,2,3-triazole hybrids represent a promising strategy for developing next-generation anticancer drugs.
• These hybrids show potential in overcoming drug resistance and reducing side effects.
• Further research into SAR and mechanisms will facilitate clinical translation.