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Klotho: A Major Shareholder in Vascular Aging Enterprises
Kenneth Lim1,2, Arvin Halim3, Tzong-Shi Lu4
1Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. kjlim@mgh.harvard.edu.
International Journal of Molecular Sciences
|September 25, 2019
Summary
Accelerated vascular aging, linked to inflammation and chronic diseases, is a growing public health issue. The protein alpha-Klotho shows anti-aging potential, but more research is needed for therapeutic use.
Area of Science:
- Gerontology
- Vascular Biology
- Molecular Medicine
Background:
- Accelerated vascular aging is a complication of prevalent inflammatory conditions like diabetes and CKD.
- Age-associated vascular changes contribute to cardiovascular disease, a leading global health problem.
- Noncommunicable diseases represent a major modern epidemic.
Purpose of the Study:
- To highlight the potential of alpha-Klotho as an anti-aging protein.
- To discuss the rationale for Klotho-based therapeutic interventions for vascular diseases.
- To identify challenges and knowledge gaps in Klotho research and clinical application.
Main Methods:
- Literature review of accelerated vascular aging and alpha-Klotho.
- Analysis of current understanding of Klotho biology.
- Identification of barriers in clinical and experimental research.
Main Results:
- Alpha-Klotho possesses significant anti-aging properties.
- Klotho holds promise for treating vascular diseases and other conditions.
- Current Klotho research is fragmented due to molecular and clinical hurdles.
Conclusions:
- Further understanding of Klotho biology is crucial.
- Overcoming experimental and clinical barriers is necessary for therapeutic development.
- Advances are critical for launching future Klotho-based interventional trials.
Keywords:
Klothoarteriosclerosischronic kidney disease (CKD), cancerdiabetesvascular agingvascular calcificationMore Related Videos
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