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Related Experiment Video

Updated: Jan 19, 2026

Zika Virus Specific Diagnostic Epitope Discovery
11:37

Zika Virus Specific Diagnostic Epitope Discovery

Published on: December 12, 2017

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Chasing Intracellular Zika Virus Using Proteomics.

Pietro Scaturro1, Anna Lena Kastner2, Andreas Pichlmair3,4

  • 1School of Medicine, Institute of Virology, Technical University of Munich, Schneckenburgerstr. 8, 81675 Munich, Germany. pietro.scaturro@tum.de.

Viruses
|September 25, 2019
PubMed
Summary
This summary is machine-generated.

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Flaviviruses cause significant human diseases. Mass spectrometry-based proteomics offers new insights into flavivirus-host interactions, particularly for Zika virus, aiding in understanding arboviral infections.

Area of Science:

  • Virology
  • Proteomics
  • Infectious Diseases

Background:

  • Flaviviruses are a major public health concern, causing endemic diseases and outbreaks with high mortality.
  • While shared replication strategies are known, individual flavivirus tropism and pathology remain poorly understood.
  • Novel proteomics technologies enable systematic investigation of virus-host interactions.

Purpose of the Study:

  • To review recent advances in mass spectrometry-based proteomics for flavivirus research.
  • To highlight the application of these techniques in understanding Zika virus.
  • To discuss the potential of proteomics in characterizing host responses to arboviruses.

Main Methods:

  • Mass spectrometry-based proteomics with high sensitivity and throughput.
Keywords:
AP-LC-MS/MSDENVLabel-free QuatificationWNVZika virusarbovirusesflavivirusesinteractomephosphoproteomicsproteomics

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  • Advanced sample preparation and bioinformatics analysis.
  • Assessment of dynamic protein alterations, turnover, and post-translational modifications.

    • Main Results:

    • Proteomics enables detailed analysis of flavivirus-host interactions.
    • Dynamic changes in host proteins during infection can be systematically identified.
    • This approach facilitates understanding of virus-specific pathobiology.

    Conclusions:

    • Mass spectrometry-based proteomics is a powerful tool for flavivirus research.
    • It offers significant potential for both basic and translational studies.
    • Understanding host responses through proteomics is crucial for combating arboviral infections.