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Calcium channel antagonists. Part V: Second-generation agents
1Department of Medicine, University of Cape Town, Medical School, Observatory, Republic of South Africa.
Cardiovascular Drugs and Therapy
|July 1, 1988
Abstract:
Second-generation agents include new dihydropyridines, such as amlodipine, felodipine, isradipine, nicardipine, nimodipine, nisoldipine, and nitrendipine. Verapamil-like agents include tiapamil, gallopamil, and anipamil. Among the diphenylalkylamines, bepridil is of special interest. New preparations of existing agents include slow-release formulations of nifedipine, verapamil, and diltiazem. From all these agents will be selected those that are longer-acting and provide higher vascular selectivity.