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Hepatitis E Virus Entry.

Xin Yin1, Zongdi Feng2,3

  • 1Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. xyin@sbpdiscovery.org.

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|September 25, 2019
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Summary
This summary is machine-generated.

Hepatitis E virus (HEV) has two infectious forms: naked and quasienveloped. Understanding how these HEV virions enter cells is key to developing treatments for Hepatitis E infection.

Keywords:
NPC1lysosomal acid lipasequasienveloped virusreceptor

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Area of Science:

  • Virology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis E virus (HEV) is a significant global cause of acute hepatitis.
  • HEV infection occurs via enteric transmission and liver replication.
  • HEV exhibits two distinct infectious forms: naked virions for fecal shedding and quasienveloped virions for bloodstream circulation.

Purpose of the Study:

  • To review and summarize the current knowledge on the cell entry mechanisms of both naked and quasienveloped HEV virions.
  • To highlight the importance of understanding HEV entry for comprehending viral biology and pathogenesis.
  • To underscore the relevance of HEV cell entry mechanisms for developing novel therapeutic and preventive strategies.

Main Methods:

  • This review synthesizes findings from recent studies on HEV cell entry.
  • It analyzes the distinct infection pathways utilized by naked and quasienveloped HEV particles.
  • Comparative analysis of virion structures and their functional implications in cell entry.

Main Results:

  • Naked HEV virions are shed in feces, mediating inter-host transmission.
  • Quasienveloped HEV virions circulate in the bloodstream, facilitating intra-host spread.
  • Both virion types are infectious but employ different cellular entry strategies.

Conclusions:

  • Elucidating the cell entry mechanisms of both HEV forms is crucial for understanding HEV pathogenesis.
  • Knowledge of HEV entry pathways is essential for the development of effective treatments and preventative measures against Hepatitis E.
  • Further research into HEV cell entry will advance strategies for controlling HEV infection globally.