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Roles of mTOR Signaling in Tissue Regeneration

Xiangyong Wei1, Lingfei Luo2, Jinzi Chen3

  • 1Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China. xiangyongwei2016@outlook.com.

Cells
|September 25, 2019
PubMed

Insights

The mammalian target of rapamycin (mTOR) pathway regulates cell growth and survival. This review explores mTOR

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • The mammalian target of rapamycin (mTOR) is a key kinase regulating cell growth, metabolism, survival, and migration.
  • mTOR functions in two complexes, mTORC1 and mTORC2, with distinct roles.
  • Dysregulation of mTOR signaling is implicated in diseases like cancer and neurodegeneration.

Purpose of the Study:

  • To review the critical roles of mTOR signaling in tissue regeneration.
  • To highlight the significance of understanding mTOR in regenerative medicine.

Main Methods:

  • Literature review of studies on mTOR signaling and tissue regeneration.
  • Analysis of mTOR's involvement in neuronal, muscle, liver, and intestinal regeneration.

Main Results:

  • mTOR signaling is activated in response to various tissue injuries.
  • mTOR plays a crucial role in the regeneration of multiple tissues, including neurons, muscles, liver, and intestine.
  • Understanding mTOR mechanisms is vital for enhancing mammalian regenerative capacity.

Conclusions:

  • mTOR signaling is a central regulator of tissue repair and regeneration across different mammalian tissues.
  • Targeting mTOR pathways holds promise for advancing regenerative medicine and treating tissue damage.
Keywords:
intestinelivermTOR signalingmetabolismmuscleneurontissue regeneration

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