Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

191
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
191
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.6K
Overview
110.6K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

200
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
200
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

225
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
225

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surface morphology-regulated tissue adhesion in solid and mesoporous silica-reinforced gelatin nanocomposite hydrogels.

Biomaterials science·2026
Same author

Effect of different poloxamers on anti-cancer activities of targeting folic acid-fucoidan nanogels for multi-drug delivery.

International journal of biological macromolecules·2026
Same author

A novel plastocyanin-like protein from <i>Strobilanthes schomburgkii</i> (Craib) J.R.I.Wood leaves: isolation and anti-inflammatory activity through MAPK signalling.

Natural product research·2025
Same author

Modulating iMSC Spheroid Function with Mechanically Tunable Hydrogels to Strengthen the Bone-Muscle Axis.

ACS biomaterials science & engineering·2025
Same author

Myogenesis and Inflammatory Response of Fibro-Adipogenic Progenitors are Regulated by Hydrogel Biophysical Properties.

ACS applied bio materials·2025
Same author

Diversity and Functional Predictions of Gut Microbiota in Vietnamese Children Aged 6-24 Months with Persistent Diarrhea of Unknown Etiology.

Pathogens (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jan 19, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

18.6K

Soy Lecithin-Derived Liposomal Delivery Systems: Surface Modification and Current Applications.

Ngoc Thuy Trang Le1, Van Du Cao2, Thi Nhu Quynh Nguyen3

  • 1Institute of Research and Development, Duy Tan University, Danang 550000, Vietnam. thuytranglengoc@gmail.com.

International Journal of Molecular Sciences
|September 25, 2019
PubMed
Summary

Soy lecithin-derived liposomes offer effective drug delivery but face rapid elimination. Surface modifications enhance their targeting, cellular uptake, and therapeutic efficacy for applications in cancer, brain targeting, and vaccines.

Keywords:
drug delivery systemliposomesoy lecithinsurface modification

More Related Videos

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

9.7K
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.5K

Related Experiment Videos

Last Updated: Jan 19, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

18.6K
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

9.7K
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.5K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacology

Background:

  • Natural phospholipids, particularly soy lecithin (SL), are crucial for nanostructured drug delivery systems.
  • Liposomes derived from SL exhibit excellent encapsulation, controlled release, and intracellular delivery capabilities due to their physicochemical properties.
  • A key limitation of liposomes is their rapid clearance from the body, necessitating surface modification strategies.

Purpose of the Study:

  • To review surface-modified liposomes for improved drug delivery.
  • To highlight how surface modifications enhance liposome targeting, cellular uptake, and therapeutic outcomes.
  • To summarize recent applications of SL-derived liposomes in cancer treatment, brain targeting, and vaccinology.

Main Methods:

  • Comprehensive literature review on surface-modified liposomes.
  • Analysis of studies focusing on soy lecithin-derived liposomes.
  • Synthesis of information on applications in oncology, neurology, and immunology.

Main Results:

  • Surface modification significantly improves liposome performance, overcoming limitations like rapid clearance.
  • Enhanced liposomes demonstrate superior targeting efficiency and cellular internalization.
  • SL-derived liposomes show promise in diverse therapeutic areas, including cancer therapy, brain drug delivery, and vaccine development.

Conclusions:

  • Surface-modified soy lecithin liposomes represent a promising platform for advanced drug delivery.
  • These modifications are key to unlocking the full therapeutic potential of liposomes.
  • Further research into SL-derived liposomes will drive innovation in targeted therapies and vaccinology.