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Abstract:
In the supplement entitled "Filoviruses: Recent Advances and Future Challenges," published with the 15 November 2007 issue of the Journal, in the article by Lofts et al. (Lofts LL, Ibrahim MS, Negley DL, Hevey MC, Schmaljohn AL. Genomic differences between guinea pig lethal and nonlethal Marburg virus variants. J Infect Dis 2007; 196:S305-12), 2 errors appeared in table 1. In the "VP40, 5116" row, the correct amino acid in the "Ci67" column is N (not D), and the correct amino acid in the "05DRC99" column is D (not N). The Journal regrets these errors.
Insights
This erratum corrects amino acid errors in a study comparing Marburg virus variants. The corrected data impacts understanding of genomic differences between lethal and nonlethal strains.
Area of Science:
- Virology
- Genomics
- Molecular Biology
Background:
- Marburg virus, a filovirus, causes severe hemorrhagic fever.
- Understanding genomic differences between virulent and avirulent strains is crucial for developing countermeasures.
- Previous research aimed to identify genetic factors distinguishing lethal and nonlethal Marburg virus variants.
Purpose of the Study:
- To correct errors in Table 1 of a previously published article.
- To ensure accurate representation of amino acid sequences for VP40 protein in Marburg virus variants.
Main Methods:
- Comparative analysis of amino acid sequences.
- Correction of specific entries in a data table.
Main Results:
- The amino acid at position 5116 in the VP40 protein for the Ci67 Marburg virus variant is N (corrected from D).
- The amino acid at position 5116 in the VP40 protein for the 05DRC99 Marburg virus variant is D (corrected from N).
Conclusions:
- Accurate genomic data is essential for reliable scientific conclusions.
- Correction of these errors ensures the integrity of the comparative analysis of Marburg virus variants.
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