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Setting surface wipe limits for skin sensitizers.

Bruce D Naumann1, Susan F Arnold2

  • 1BD NAUMANN LLC, Flemington, NJ, USA.

Toxicology and Industrial Health
|September 25, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a quantitative method for setting surface wipe limits for skin sensitizers, using data from the murine local lymph node assay (LLNA). This approach aids in managing dermal exposure risks in the workplace.

Keywords:
Exposure assessmentOEBshazard identificationrisk assessmentsensitization potency

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Area of Science:

  • Toxicology
  • Occupational Health
  • Industrial Hygiene

Background:

  • Historically, managing dermal exposure to skin sensitizers relied on qualitative guidance like DSEN notations.
  • Quantitative methods for establishing surface wipe limits for skin sensitizers were lacking.

Purpose of the Study:

  • To propose and validate a quantitative method for setting surface wipe guidelines for skin sensitizers.
  • To utilize the murine local lymph node assay (LLNA) EC3 values for developing these guidelines.

Main Methods:

  • Correlating LLNA EC3 values with human repeat insult patch testing no-effect levels.
  • Developing a quantitative method to derive surface wipe limits from LLNA EC3 data.
  • Establishing occupational exposure bands and handling guidance based on sensitizer potency.

Main Results:

  • A quantitative method for setting surface wipe limits for skin sensitizers was developed.
  • The method leverages the quantitative dose-response information from the LLNA EC3 value.
  • A table of suggested surface wipe limits (mg/100 cm²) for chemical sensitizers is provided.

Conclusions:

  • The proposed quantitative method allows for the establishment and use of surface wipe limits for skin sensitizers.
  • These limits support exposure assessment and control strategies within industrial hygiene programs.
  • Implementing these guidelines can minimize skin exposure and sensitization risks in the workplace.