Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cellular basis for suppressive rod-cone interaction.

T E Frumkes1, T Eysteinsson

  • 1Department of Psychology, Queens College of CUNY, Flushing, 11367.

Visual Neuroscience
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Oscillatory potentials in the retina: the effects of GABA agonists.].

Laeknabladid·2010
Same author

Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension.

The British journal of ophthalmology·2009
Same author

[Light adaptation of cones in rabbits and guinea pigs.].

Laeknabladid·2006
Same author

Epidemiology of the optic nerve grey crescent in the Reykjavik Eye Study.

The British journal of ophthalmology·2004
Same author

Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing.

The British journal of ophthalmology·2004
Same author

Optic nerve oxygen tension: the effects of timolol and dorzolamide.

The British journal of ophthalmology·2004

Dim backgrounds enhance visual responses through suppressive rod-cone interaction (SRCI). This interaction, mediated by horizontal cells, involves rods suppressing cone pathways, impacting vision, especially with rapid flickering stimuli.

Area of Science:

  • Neuroscience
  • Vision Science
  • Retinal Physiology

Background:

  • Rods and cones are photoreceptors with distinct roles in vision.
  • Suppresssive rod-cone interaction (SRCI) is a phenomenon where rod activity influences cone pathways.
  • Understanding SRCI is crucial for comprehending visual processing under varying light conditions.

Purpose of the Study:

  • To investigate the mechanisms underlying suppressive rod-cone interaction (SRCI).
  • To determine the role of horizontal cells in mediating SRCI.
  • To compare SRCI across different species, including amphibians, cats, and humans.

Main Methods:

  • Intracellular recordings from retinal cells in amphibians.
  • Utilizing flicker stimuli at high frequencies.

Related Experiment Videos

  • Employing glutamate analogs and lead chloride to block specific cellular responses.
  • Measuring spatial constants in horizontal cells.

    • Main Results:

    • SRCI enhances responses to focal flicker stimuli with dim, diffuse rod-backgrounds.
    • SRCI is mediated by horizontal cells and involves rod-modulation of cone pathways.
    • SRCI is blocked by agents affecting horizontal cell photic responses and rod activity.
    • A consistent spatial constant for SRCI was observed across amphibians, cats, and humans.

    Conclusions:

    • Horizontal cells play a key role in mediating suppressive rod-cone interaction (SRCI).
    • SRCI involves a tonic suppressive influence of rods on cone pathways.
    • The findings suggest a conserved mechanism of visual processing across species.