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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Cell Migration01:19

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Related Experiment Video

Updated: Jan 19, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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Myeloid Cells in Metastasis.

Agnieszka Swierczak1, Jeffrey W Pollard1

  • 1MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.

Cold Spring Harbor Perspectives in Medicine
|September 25, 2019
PubMed
Summary

Myeloid cells, including macrophages and neutrophils, significantly impact cancer metastasis. Understanding these myeloid cell roles in the metastatic cascade offers new therapeutic targets for cancer immunotherapy.

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Metastatic disease is the primary cause of cancer-related mortality.
  • Metastasis is a complex, multistep process involving tumor cell detachment, circulation, and secondary organ colonization.
  • Tumor and immune cell interactions are critical throughout the metastatic cascade.

Purpose of the Study:

  • To review the mechanisms by which myeloid cells promote cancer metastasis.
  • To highlight the role of myeloid cells in enhancing the metastatic cascade.
  • To identify potential therapeutic targets within myeloid cell-mediated metastasis.

Main Methods:

  • Literature review of current research on myeloid cells and cancer metastasis.
  • Analysis of pathways and mechanisms involved in myeloid cell-driven metastasis.

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  • Synthesis of findings on myeloid cell interactions within the tumor microenvironment and systemically.

    • Main Results:

    • Myeloid cells, such as monocytes, macrophages, neutrophils, and myeloid-derived suppressor cells, play crucial roles in facilitating metastasis.
    • These myeloid cells influence multiple steps of the metastatic cascade, from primary tumor progression to secondary site colonization.
    • Interactions between tumor cells and myeloid cells are vital for systemic spread and immune evasion.

    Conclusions:

    • Myeloid cells are key regulators of cancer metastasis, influencing tumor cell survival, migration, and immune evasion.
    • Targeting myeloid cell functions presents a promising strategy for developing novel cancer immunotherapies.
    • Further research into myeloid cell-mediated metastatic pathways can lead to improved patient outcomes.