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Related Experiment Video

Updated: Jan 19, 2026

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
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Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

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Early Graft Dysfunction after Lung Transplantation.

Justin Rosenheck1, Colleen Pietras2, Edward Cantu2

  • 1Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine.

Current Pulmonology Reports
|September 25, 2019
PubMed
Summary

Primary graft dysfunction (PGD) is a lung injury after transplantation. Advances in PGD research include better prediction, targeted therapies, and improved management with ECMO for severe cases.

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Area of Science:

  • Transplantation immunology
  • Acute lung injury research
  • Pulmonary medicine

Background:

  • Primary graft dysfunction (PGD) is a critical complication following lung transplantation.
  • It represents an acute lung injury syndrome with significant impact on patient outcomes.

Purpose of the Study:

  • To review the current understanding of PGD, encompassing its epidemiology, immunology, clinical outcomes, and management strategies.
  • To highlight recent advancements in PGD research and clinical practice.

Main Methods:

  • Literature review focusing on PGD epidemiology, immunology, biomarkers, prediction, and therapeutic interventions.
  • Analysis of current management strategies, including supportive care and extracorporeal membrane oxygenation (ECMO).
Keywords:
Lung TransplantationPrimary graft dysfunctionacute lung injuryex-vivo lung perfusionischemia-reperfusion injury

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Related Experiment Videos

Last Updated: Jan 19, 2026

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
07:28

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Published on: October 11, 2024

712
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

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Orthotopic Left Lung Transplantation in Rats
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Orthotopic Left Lung Transplantation in Rats

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Main Results:

  • Progress has been made in identifying donor and recipient factors for PGD prediction.
  • Understanding of PGD immunology is improving, leading to biomarker research.
  • Donor lung expansion strategies, including ex vivo lung perfusion, are advancing.
  • ECMO plays a key role in managing severe PGD.

Conclusions:

  • A consensus definition of PGD has facilitated research and clinical care improvements.
  • Future research is expected to yield reliable predictive tools and targeted therapies for PGD.