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Updated: Jan 19, 2026

Fabrication of Three-Dimensional Graphene-Based Polyhedrons via Origami-Like Self-Folding
Published on: September 23, 2018
Two-dimensional supramolecular assemblies based on β-cyclodextrin-grafted graphene oxide for mitochondrial
Bing Zhang1, Qilin Yu2, Ying-Ming Zhang3
1College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
New graphene oxide (GO) nanoassemblies carrying beta-cyclodextrin (CD) can target tumor cell mitochondria. These assemblies offer photocontrollable disruption and high near-infrared-induced photothermal efficiency for cancer therapy.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Photomedicine
Background:
- Graphene oxide (GO) and beta-cyclodextrin (CD) are explored as drug carriers.
- Targeting tumor cell mitochondria is a key strategy in cancer therapy.
- Photocontrollable drug delivery systems offer spatiotemporal precision.
Purpose of the Study:
- To develop novel two-dimensional nano-supramolecular assemblies.
- To specifically target and disrupt tumor cell mitochondria.
- To investigate near-infrared-induced photothermal efficiency for cancer treatment.
Main Methods:
- Grafting beta-cyclodextrin (CD) onto graphene oxide (GO).
- Fabrication of two-dimensional nano-supramolecular assemblies.
- Evaluation of targeting specificity and disruption of tumor cell mitochondria.
- Assessment of photothermal efficiency under near-infrared irradiation.
Main Results:
- Successfully synthesized CD-grafted GO nanoassemblies.
- Demonstrated specific targeting and disruption of tumor cell mitochondria.
- Achieved extremely high photothermal conversion efficiency upon near-infrared light stimulation.
Conclusions:
- CD-grafted GO nanoassemblies are effective for targeted cancer therapy.
- The photothermal effect provides a photocontrollable mechanism for tumor cell disruption.
- These nanoassemblies show significant potential as advanced drug delivery systems.
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