Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

MALDI-TOF Mass Spectrometry

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...

Mass Spectrometry: Complex Analysis

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Image feature embedding with a deep learning framework improves genome-wide association studies on dog endophenotypes.

Science advances·2026

Same author

Social communicative characteristics of adolescent police dogs: Acquired experience plays a crucial role.

Animal cognition·2026

Same author

Huazhuo Decoction Contributes to Immune Homeostasis and Attenuates Neuronal Inflammation and Demyelination in a Mouse Model of Multiple Sclerosis.

Journal of inflammation research·2026

Same author

Neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors improves survival from resectable hepatocellular carcinoma in a multicenter, retrospective study (GUIDANCE002).

Communications medicine·2026

Same author

Clinical and Prognostic Features of Perioperative Stroke: A Multicenter Retrospective Cohort Study.

Cerebrovascular diseases extra·2026

Same author

Prognostic Usefulness of Clinical Complete Response after PD-1 Inhibitor-Based Combination Therapy for Unresectable Hepatocellular Carcinoma (GUIDANCE006).

Liver cancer·2026

Same journal

Construction and implementation of an ICF-based integrated teaching model for genetic disease severity assessment.

Yi chuan = Hereditas·2026

Same journal

Identification and prenatal genetic testing of pathogenic variants in a case of myoclonus-dystonia syndrome.

Yi chuan = Hereditas·2026

Same journal

A novel strategy to enhance precise targeting of the RNA base editor mxABE.

Yi chuan = Hereditas·2026

Same journal

Functional study of the soybean rapid alkalinization factor <i>GmRALF34s</i> in response to saline-alkali stress.

Yi chuan = Hereditas·2026

Same journal

Role of <i>broad</i> in intestinal stem cells of adult <i>Drosophila</i>.

Yi chuan = Hereditas·2026

Same journal

The p53 R267W mutation intervenes p21-mediated cell cycle arrest and promotes proliferation and migration of lung cancer cells.

Yi chuan = Hereditas·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 19, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

[Current metabolomics platforms: technical composition and applications].

Feng-Xia Zhang¹, Guo-Dong Wang¹

¹State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.

Yi Chuan = Hereditas

|September 25, 2019

Summary

This summary is machine-generated.

Metabolomics, a comprehensive chemical analysis, uses high-resolution chromatography-mass spectrometry for biological studies. This technology enables qualitative and quantitative analysis across diverse research fields.

More Related Videos

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

Related Experiment Videos

Last Updated: Jan 19, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

Area of Science:

Systems Biology
Analytical Chemistry

Background:

Metabolomics is crucial for systems biology, alongside genomics and proteomics.
Chromatography-mass spectrometry (CMS) offers high resolution and sensitivity for metabolomics.
Advancements in CMS technology have expanded metabolomics applications in biology.

Purpose of the Study:

To review different chromatography-mass spectrometry machines for metabolomics.
To illustrate CMS applications in biological research using a case study.

Main Methods:

Utilizing chromatography-mass spectrometry (CMS) for metabolomics analysis.
Qualitative and quantitative analysis of small molecules.
Case study of the Institute of Genetics and Developmental Biology's metabolomics platform.

Main Results:

Demonstrated the versatility of CMS in various biological research areas.
Highlighted the practical applications of metabolomics platforms.

Conclusions:

Chromatography-mass spectrometry is a key technology for modern metabolomics.
Metabolomics analysis via CMS has broad applications in understanding biological systems.