Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

3.0K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.0K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

8.8K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.8K
The Blood-brain Barrier00:49

The Blood-brain Barrier

52.5K
Overview
52.5K
Introduction to Hemostasis01:05

Introduction to Hemostasis

13.5K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
13.5K
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

5.4K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
5.4K
Coagulation01:09

Coagulation

9.7K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Objectively Measured Cardiorespiratory Fitness as a Potential Biomarker for Alzheimer's Disease Risk in Older Adults: Evidence from the Generation 100 Study.

Medicine and science in sports and exercise·2026
Same author

Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging.

Cell stem cell·2026
Same author

Effects of 5-Year Exercise Training on Cognition in Older Adults: 10-Years Follow-Up from the Generation 100 Study.

Sports medicine - open·2025
Same author

Longitudinal Associations between Cardiorespiratory Fitness and Cognition in Older Adults: A 10-Year Follow-Up from the Generation 100 Study.

Medicine and science in sports and exercise·2025
Same author

Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis.

Biomaterials·2025
Same author

Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing.

Lancet (London, England)·2025
Same journal

Deletion of Fbxo25 causes excessive repetitive behavior, impaired recognition memory, reduced dendritic complexity, and aberrant protein expression in mice.

Progress in neurobiology·2026
Same journal

Neuropsychiatric Disease Mechanisms and Interventions. from 22q11.2 Deletion Syndrome Experimental Studies.

Progress in neurobiology·2026
Same journal

REM sleep as a dummy-model of the world: A theoretical framework.

Progress in neurobiology·2026
Same journal

CA3 transiently modulates spatial representation in CA1.

Progress in neurobiology·2026
Same journal

Love, death, and oxytocin: In memory of Larry Young.

Progress in neurobiology·2026
Same journal

Assessing peripheral oxytocin and cortisol levels and epigenetic variations of oxytocin receptor and glucocorticoid receptor genes in school-aged preterm-born children.

Progress in neurobiology·2026
See all related articles

Related Experiment Video

Updated: Jan 19, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.0K

Platelets: The missing link between the blood and brain?

Odette Leiter1, Tara L Walker1

  • 1Queensland Brain Institute (QBI), The University of Queensland, Brisbane 4072, Australia.

Progress in Neurobiology
|September 25, 2019
PubMed
Summary
This summary is machine-generated.

Platelets, beyond wound healing, actively support brain health. These cells communicate with brain cells, potentially enhancing neurogenesis and cognitive function in aging and disease.

Keywords:
Adult neurogenesisBrain functionBrain plasticityCell-cell communicationNeurodegenerationPlatelets

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.6K
Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

12.1K

Related Experiment Videos

Last Updated: Jan 19, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.0K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.6K
Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

12.1K

Area of Science:

  • Neuroscience
  • Immunology
  • Hematology

Background:

  • Peripheral immune system and central nervous system interactions are crucial for brain health.
  • Platelets, traditionally known for hemostasis, possess diverse, underappreciated functions.

Purpose of the Study:

  • To summarize platelet functions relevant to brain homeostasis.
  • To propose mechanisms of platelet-brain cell communication.
  • To highlight platelets' role in neurogenesis and cognitive function.

Main Methods:

  • Literature review and synthesis of current research on platelet biology.
  • Analysis of proposed mechanisms of platelet-brain interaction (e.g., exosome release, receptor signaling).
  • Focus on platelet-mediated modulation of neural precursor cells.

Main Results:

  • Platelets contribute to maintaining brain homeostasis through various mechanisms.
  • Platelet communication with brain cells involves releasing exosomes and microparticles.
  • Platelets modulate neural precursor cell differentiation, impacting neurogenesis.

Conclusions:

  • Platelets play a significant role in brain plasticity and neurogenesis.
  • Understanding platelet-brain interactions offers therapeutic potential for cognitive decline.
  • Targeting platelet functions could promote cognitive health in aging and disease.