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Correlates of current rapid-cycling bipolar disorder: Results from the Italian multicentric RENDiBi study
Massimiliano Buoli1, Bruno Mario Cesana2, Giuseppe Maina3
1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy.
Summary
Recurrent cyclothymia (RC) in bipolar disorder (BD) is more common in females and linked to higher hospitalization risk. Early diagnosis and personalized treatment for RC patients are crucial for better management.
Area of Science:
- Psychiatry
- Clinical Psychology
- Neuroscience
Background:
- Bipolar disorder (BD) presents significant challenges in diagnosis and treatment.
- Recurrent cyclothymia (RC) is a specifier within BD that requires further investigation.
- Understanding factors associated with RC can improve patient outcomes.
Purpose of the Study:
- To compare socio-demographic and clinical characteristics of BD patients with and without current RC.
- To identify clinical factors associated with RC for early diagnosis and personalized treatment strategies.
Main Methods:
- A cohort of 1675 BD patients was analyzed.
- Patients were categorized based on the presence of current RC.
- Statistical analyses included Chi-squared tests, Student's t tests, and multivariable logistic regression.
Main Results:
- Female gender was associated with RC (OR=0.64, p=0.04).
- Unidentifiable prevalent polarity (OR=1.76, p=0.02) and manic polarity (OR=2.86, p<0.01) were linked to RC.
- Increased hospitalization in the last year showed an association with RC (OR=0.63, p=0.02).
Conclusions:
- RC in BD appears more prevalent in females.
- RC is associated with unfavorable clinical features, including increased hospitalization risk.
- Clinical management and monitoring should consider these factors for RC patients.