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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
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Engineering of flexible granular Au nanocap ordered array and its surface enhanced Raman spectroscopy effect
Peng Zhang1,2, Guangqiang Liu1,3, Sujuan Feng3
1Key Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.
Nanotechnology
|September 25, 2019
Summary
Researchers developed flexible gold nanocap SERS substrates using reactive ion etching. These cost-effective substrates offer high sensitivity and uniformity for detecting organic molecules in flexible devices.
Area of Science:
- Materials Science
- Analytical Chemistry
- Nanotechnology
Background:
- Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique for chemical and biological detection.
- Traditional rigid SERS substrates limit applications in flexible electronic devices.
- There is a growing need for adaptable and high-performance SERS platforms.
Purpose of the Study:
- To develop a simple, cost-effective, and scalable method for preparing flexible SERS substrates.
- To investigate the efficacy of reactive ion etching (RIE) for creating nanostructured surfaces for SERS.
- To demonstrate the high sensitivity and uniformity of the fabricated flexible SERS substrates.
Main Methods:
- Fabrication of flexible SERS substrates using reactive ion etching (RIE) to nanoroughen polystyrene (PS) spheres.
- Subsequent gold (Au) deposition to form ordered arrays of gold nanocaps (AuNCs).
- Finite-difference time-domain (FDTD) simulations to analyze electric field enhancement.
Main Results:
- RIE proved effective for nanoroughening PS spheres, enabling uniform AuNC formation.
- The flexible SERS substrates demonstrated high sensitivity and uniformity in detecting organic molecules.
- FDTD simulations confirmed strong electric field coupling at inter-nanoparticle gaps and AuNC-nanoparticle junctions.
Conclusions:
- A novel and efficient method for nanostructuring PS spheres was established.
- The developed flexible AuNC SERS substrates are cost-effective and suitable for sensitive organic molecule detection.
- This work advances the development of SERS technology for flexible analytical devices.

