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Updated: Jan 19, 2026

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
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Radially patterned polycaprolactone nanofibers as an active wound dressing agent.

Dongwoo Shin1, Min Sup Kim2, Chae Eun Yang3

  • 1Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Archives of Plastic Surgery
|September 25, 2019
PubMed
Summary

Engineered radial nanofibers using modified electrospinning show similar mechanical strength to random nanofibers. These patterned scaffolds enhance stem cell migration, indicating potential for tissue regeneration applications.

Keywords:
NanofibersPolycaprolactonePolymersWound healing

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Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Developing novel nanofiber scaffolds is crucial for advancing tissue regeneration.
  • Polycaprolactone (PCL) nanofibers are widely studied for biomedical applications.
  • Controlled nanofiber alignment can influence cellular behavior and tissue integration.

Purpose of the Study:

  • To design and fabricate radially patterned polycaprolactone (PCL) nanofibers using a modified electrospinning technique.
  • To compare the mechanical and biological properties of radially patterned PCL nanofibers with randomly deposited nanofibers.
  • To evaluate the impact of radial nanofiber architecture on human bone marrow stem cell migration.

Main Methods:

  • Modified electrospinning was employed to create radially patterned PCL nanofibers.
  • Scanning electron microscopy (SEM) was used to analyze surface morphology and nanofiber directionality.
  • Uniaxial tensile testing assessed the mechanical properties of the nanofibrous mats.
  • Human bone marrow stem cells were cultured on scaffolds, and their migration towards the center was tracked and quantified over 7 days using fluorescence imaging and ImageJ software.

Main Results:

  • No significant differences in mechanical properties were observed between radially patterned and randomly deposited PCL nanofibers.
  • SEM confirmed the radial alignment of nanofibers directed towards the center of the scaffold.
  • Radially aligned nanofibers significantly enhanced stem cell migration compared to random nanofibers, particularly evident on days 4 and 7.

Conclusions:

  • Modified electrospinning successfully produced radially aligned PCL nanofibers with comparable mechanical properties to random nanofibers.
  • The radially aligned structure significantly promoted faster stem cell migration.
  • These findings suggest that radially aligned nanofibers hold promise for tissue regeneration strategies when combined with stem cells.