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Murine candidiasis: strain dependence of host responses after immunization
R B Ashman1, J M Papadimitriou
1Clinical Immunology Research Unit, Princess Margaret Hospital for Children, Subiaco, WA.
Immunology and Cell Biology
|January 1, 1988
Summary
Mice infected with Candida albicans develop resistance, but CBA/H mice show stronger protection against fungal colonization and brain lesions than BALB/c mice. Granulocyte function did not explain this difference.
Area of Science:
- Immunology
- Microbiology
- Infectious Diseases
Background:
- Candida albicans is an opportunistic fungal pathogen.
- Host immune responses determine susceptibility to fungal infections.
- Murine models are crucial for studying host-pathogen interactions.
Purpose of the Study:
- To investigate differences in protective immune responses to Candida albicans between CBA/H and BALB/c mice.
- To determine the role of granulocyte function in differential resistance patterns.
Main Methods:
- Induction of acute Candida albicans infection in CBA/H and BALB/c mice.
- Assessment of resistance to fungal colonization and lesion severity post-infection.
- Analysis of granulocyte function in naive and immune mice.
Main Results:
- Both mouse strains exhibited increased resistance after recovery from acute infection.
- CBA/H mice displayed significantly stronger protective responses, including reduced brain lesions and fungal burden, compared to BALB/c mice.
- Granulocyte function analysis did not reveal significant differences that could account for the observed variations in resistance.
Conclusions:
- Host genetic background significantly influences the development of protective immunity against Candida albicans.
- CBA/H mice mount a more effective immune response against Candida albicans colonization than BALB/c mice.
- Granulocyte function is unlikely to be the primary factor driving the differential susceptibility observed between these mouse strains.