Related Experiment Videos
Murine candidiasis: strain dependence of host responses after immunization
R B Ashman1, J M Papadimitriou
1Clinical Immunology Research Unit, Princess Margaret Hospital for Children, Subiaco, WA.
Immunology and Cell Biology
|January 1, 1988
Abstract:
After recovery from acute infection with live Candida albicans, both CBA/H and BALB/c mice show increased resistance to colonization by the organism. However, the 'susceptible' CBA/H mice develop much stronger protective responses than do 'resistant' BALB/c mice. This is manifested particularly as a substantial amelioration of the severity of the lesions in the brain, and a very marked reduction in the number of fungal units therein. Analysis of granulocyte function in normal and immune mice of the two strains tended to exclude this as a basis for the different patterns of susceptibility and resistance.