Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

59.4K
Overview
59.4K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.3K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.3K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

601
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
601
Genomics02:02

Genomics

39.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.7K
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

48.3K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
48.3K
Global Regulatory Systems01:28

Global Regulatory Systems

612
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
612

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of enteric viral pathogens in Tanzanian children under the age of five with diarrhea using nanopore-based metagenomic sequencing.

Virology·2026
Same author

Matrix extension to bovine feces and evaluation of semi-automated DNA extraction methods for the detection of <i>Campylobacter jejuni</i> in bovine and canine fecal samples using <i>gyrA</i> PCR.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2026
Same author

Microbial composition of archaeological middens: tracing human footprints through centuries in Greenland's ancient settlements.

Frontiers in microbiology·2026
Same author

Author Correction: Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes.

Nature communications·2026
Same author

Whole-genome sequencing reveals a previously unrecognized measles virus cluster in Burundi.

PloS one·2026
Same author

Large-scale whole-genome sequencing of animal clinical Salmonella enterica demonstrates relatedness to human cases.

Veterinary microbiology·2026

Related Experiment Video

Updated: Jan 19, 2026

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.5K

Using Genomics to Track Global Antimicrobial Resistance.

Rene S Hendriksen1, Valeria Bortolaia1, Heather Tate2

  • 1European Union Reference Laboratory for Antimicrobial Resistance, World Health Organisation, Collaborating Center for Antimicrobial Resistance and Genomics in Food borne Pathogens, FAO Reference Laboratory for Antimicrobial Resistance, National Food Institute, Technical University of Denmark, Lyngby, Denmark.

Frontiers in Public Health
|September 26, 2019
PubMed
Summary

Advancements in DNA sequencing and bioinformatics tools enable rapid antimicrobial resistance (AMR) detection. This review highlights over 47 resources for AMR surveillance, crucial for combating the growing AMR threat globally.

Keywords:
antimicrobial resistancebioinformatics toolsgenomicglobalmicrobiologysurveillance

More Related Videos

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.7K
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

14.2K

Related Experiment Videos

Last Updated: Jan 19, 2026

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.5K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.7K
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

14.2K

Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • Rapid DNA sequencing and bioinformatics tools have transformed microbial surveillance and diagnostics.
  • Antimicrobial resistance (AMR) poses a significant global health threat, necessitating advanced detection methods.

Purpose of the Study:

  • To review and describe available bioinformatics tools and databases for detecting antimicrobial resistance (AMR) determinants.
  • To provide future perspectives and recommendations for AMR detection and surveillance.

Main Methods:

  • Scientific literature review of bioinformatics resources for AMR detection.
  • Categorization and description of identified tools based on input data, database content, and search approach.

Main Results:

  • Over 47 freely accessible bioinformatics resources for AMR detection have been identified.
  • Tools vary in input data, database scope, and search strategies (mapping vs. alignment), impacting sensitivity and specificity.
  • Resources are available via public data centers, GitHub, or local installations; NCBI and ENA allow data submission.

Conclusions:

  • Accessible bioinformatics tools and sequence data are expanding, facilitating global AMR surveillance and tracking.
  • Standardization of pipelines, databases, and phenotypic predictions is needed for robust AMR detection and control strategies.