Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

514
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
514
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

472
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
472
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

364
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
364
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

1.7K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.7K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

584
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
584
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.7K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative Risk Assessment and Shared Decision-Making in Older Patients Eligible for Cardiac Surgery: Protocol for a Non-Randomized Prospective Study.

Healthcare (Basel, Switzerland)·2026
Same author

Response to the letter to the editor: Epicardial, visceral and subcutaneous adipose tissue in heart failure with preserved ejection fraction.

ESC heart failure·2026
Same author

Prognostic value of the baseline CAVIAR response score after cardiac resynchronization therapy: 10-year outcomes from the Markers and Response to CRT study.

Heart rhythm·2026
Same author

Development of Atrial Fibrillation in patients with Heart Failure and vice versa: Incidence, risk factors, and their impact on survival.

ESC heart failure·2026
Same author

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.

Research square·2026
Same author

Rate control treatment with calcium channel blockers and beta blockers for patients with atrial fibrillation: a systematic review and meta-analysis.

European heart journal open·2026

Related Experiment Video

Updated: Jan 19, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.9K

Atrial Fibrillation Genetics Update: Toward Clinical Implementation.

Silje Madeleine Kalstø1, Joylene Elisabeth Siland2, Michiel Rienstra2

  • 1Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Rud, Norway.

Frontiers in Cardiovascular Medicine
|September 26, 2019
PubMed
Summary

Atrial fibrillation (AF) is a common heart rhythm disorder with serious consequences. Genetic factors play a significant role, and understanding AF genetics aids clinical decision-making.

Keywords:
atrial fibrillationgeneticsgenome-wide association studies (GWAS)heritabilitypersonalized medicineprecision medicinerisk factorswhole genome sequencing

More Related Videos

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
08:05

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

3.4K
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.4K

Related Experiment Videos

Last Updated: Jan 19, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.9K
Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
08:05

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

3.4K
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.4K

Area of Science:

  • Cardiology
  • Genetics
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) is the most prevalent heart rhythm disorder globally.
  • AF significantly increases the risk of stroke, dementia, heart failure, and mortality.
  • Established clinical risk predictors include male sex, advanced age, and hypertension.

Purpose of the Study:

  • To provide an overview of the genetics of atrial fibrillation.
  • To guide clinicians in interpreting genetic advances for AF prediction and management.
  • To explore the role of genetics in understanding AF mechanisms and patient-specific care.

Main Methods:

  • Review of current literature on AF genetics.
  • Analysis of genetic variants associated with AF.
  • Discussion of polygenic risk scoring and its application.
  • Exploration of genetic insights into AF pathophysiology.

Main Results:

  • A substantial genetic component underlies AF development.
  • Recent discoveries have accelerated the identification of novel AF-related genetic variants.
  • Genetics offers potential for improved risk prediction and targeted therapies for AF.

Conclusions:

  • Interpreting the role of genetics in AF prediction and management remains challenging for clinicians.
  • Advances in AF genetics are crucial for developing personalized treatment strategies.
  • Further research is needed to integrate genetic findings into routine clinical practice for AF patients.