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Oral nitroglycerin in angina pectoris--evaluation of effect by computerized exercise testing using two different
R S Kohli1, N S Khurmi, M M Kardash
1Cardiology Department, Northwick Park Hospital, Harrow, England.
Cardiovascular Drugs and Therapy
|November 1, 1988
Summary
Sustained-release oral nitroglycerin effectively treats chronic stable angina. This study confirmed its anti-anginal efficacy without significant tolerance development over two weeks.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Chronic stable angina is a prevalent condition requiring effective management.
- Oral nitroglycerin formulations aim to provide sustained antianginal effects.
Purpose of the Study:
- To evaluate the antianginal efficacy of sustained-release oral nitroglycerin.
- To assess for a dose-response relationship and tolerance development.
Main Methods:
- Double-blind, randomized, placebo-controlled crossover trial.
- 17 patients with chronic stable angina completed the study.
- Graded treadmill exercise testing with EKG analysis was used to assess efficacy.
Main Results:
- Oral nitroglycerin significantly increased exercise time compared to placebo (p<0.02 for 2.6 mg, p<0.01 for 6.5 mg).
- No significant dose-response relationship was observed.
- No significant attenuation of effect or tolerance was noted with continued administration.
Conclusions:
- Sustained-release oral nitroglycerin demonstrates antianginal efficacy in chronic stable angina.
- The drug appears to be effective without significant tolerance development over a two-week period.
- Further research may explore long-term efficacy and tolerance.