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Ceftobiprole: drug evaluation and place in therapy
Daniele Roberto Giacobbe1,2, Francesco Giuseppe De Rosa3, Valerio Del Bono4
1Department of Health Sciences, University of Genoa , Genoa , Italy.
Expert Review of Anti-Infective Therapy
|September 26, 2019
Summary
Ceftobiprole, a fifth-generation cephalosporin, is effective for community-acquired and hospital-acquired pneumonia due to its broad spectrum and activity against MRSA. Its safety profile makes it a valuable option for both approved and potential off-label uses.
Area of Science:
- Infectious Diseases
- Pharmacology
- Antimicrobial Stewardship
Background:
- Ceftobiprole is a fifth-generation cephalosporin with broad-spectrum antimicrobial activity.
- It is approved for community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP) in many countries.
Purpose of the Study:
- To review the current therapeutic role of ceftobiprole.
- To discuss its use within and outside of approved indications.
Main Methods:
- A narrative review of existing literature.
- An inductive search of MEDLINE/PubMed was performed.
Main Results:
- Ceftobiprole is attractive for CAP and HAP due to its broad spectrum, activity against methicillin-resistant Staphylococcus aureus (MRSA), and safety profile.
- Off-label use may be justified in cases of treatment failure, unacceptable toxicity of alternatives, or as salvage therapy.
Conclusions:
- Ceftobiprole is a valuable option for empirical and targeted treatment of CAP and HAP.
- Further research may expand its approved indications and inform off-label use.
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